The Effect of a High-Sucrose Diet on the Calcium and Phosphorus

It was demonstrated by Barrett, Best & Ridout (1938) that the administration of APP to fasting mice caused rapid mobilization of lipid from the depots with an accumulation of lipid in the liver. Stetten & Salcedo (1944) demonstrated this effect in rats. The results of the present study in mice and rats support and extend these findings. The glyceride fraction was principally affected in the mobilization of lipid produced by the anterior pituitary stimulation. Glycerides were removed from the depots, were deposited in liver, and were utilized to a greater extent than any other lipid fraction examined. While no attempt is made to explain the mechanism of lipid mobilization, it seems probable from the evidence available that the rate of mobilization from a tissue may be related to the glyceride content of that tissue. The liver and, to a much less extent, the kidney were the only structures of those examined whose lipid contents increased during the period of lipid mobilization.